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) пппThe darkness of the central area of the anatomic macula as seen in fluorescein angiograms is caused by four factors (1) the yellow pigment (xanthochrome) present mainly in the filagra effects layers of the central macular retina; (2) the cen- tral avascular zone; (3) the taller, nar- rower RPE cells, which contain more melanin filagra effects per unit than else- where; and (4) the increased concentra- tion in the central macular RPE of lipofuscin, which acts as an orange fil- ter in filtering out the fluorescence.
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