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(From Moyers and Lesyna, Int J Radiat Oncol Biol Phys, 60(5), 1622, 2004. 534в535 in this chapter). Since ABCC1 and ABCC4 have been shown to function as a prostaglandin derivate efflux transporter (71в73) and IL-6-type cytokines are known to induce the expression of COX-2 in certain cell types (74, 75), it is tempting to speculate that increased prosta- glandin efflux might be one additional means by which IL-6 can contribute to inflammation.
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